Approximately 70% of primary care visits involve a behavioral health component, yet most nurses have never received formal training in psychiatric screening, brief intervention, or integrated care coordination. The result is a workforce that encounters depression, anxiety, substance use, and trauma every day but lacks the tools to respond systematically. A Practical Clinical Guide Built for the Primary Care Nurse This guide bridges the gap between what nursing schools teach and what integrated behavioral health demands. It covers validated screening instruments, brief evidence-based interventions, psychotropic medication monitoring, patient registry management, and the workflows that make the Collaborative Care Model function in real clinical settings. Every chapter reflects current research, including over 90 randomized controlled trials supporting collaborative care, and 2026 CMS billing updates. Screening Tools and Protocols You Can Use Immediately Detailed guides for the PHQ-9, GAD-7, AUDIT-C, PC-PTSD-5, Columbia Suicide Severity Rating Scale, and more than a dozen additional instruments are provided with scoring thresholds, clinical decision algorithms, and action protocols. Reproducible workflow templates, safety planning forms, care transition checklists, and documentation examples are included for direct clinical use. From Measurement-Based Care to Financial Sustainability Build and maintain a patient registry, prepare for weekly psychiatric caseload reviews, track treatment response and remission rates, and bill CoCM codes (99492, 99493, 99494) alongside the new 2026 APCM behavioral health add-on codes. The billing guide covers Medicare, Medicaid, and commercial payer requirements with time-tracking strategies that maximize reimbursement. 28 Chapters and 9 Appendices of Comprehensive Coverage Topics span behavioral health integration models, therapeutic communication and motivational interviewing, behavioral activation, warm handoff protocols, psychopharmacology, crisis management and suicide risk assessment, cultural responsiveness, substance use management, lifespan care from pediatric through geriatric, telehealth, nurse wellness, and career pathways from RN care manager to PMHNP. Each chapter includes case studies, applied practice sections, and APA-cited references. Built for Primary Care Nurses Ready to Lead RN care managers, nurse care coordinators, family practice nurses, FQHC clinic nurses, and nurses moving into behavioral health integration roles will find the clinical knowledge, practical tools, and professional development guidance needed to function in collaborative care teams and drive measurable patient outcomes.