Chronotherapeutics form a set of non-pharmacologic methods that impact circadian rhythms and sleep in the service of improved antidepressant efficacy. The exemplar is bright light therapy, the treatment of choice for seasonal affective disorder, supported by controlled clinical trials worldwide. An expanded research base demonstrates that seasonal variation is not a limiting key to treatment efficacy: non-seasonal major depression as well as bipolar disorder also respond to light therapy. This manual further extends the applicable domain to a set of psychiatric and neurologic illnesses, including sleep medicine. Importantly, the authors present a complementary, if counterintuitive, intervention - wake therapy - which can alleviate major depression within hours, exclusive of medication. Imaging studies reveal that both light and wake therapy share neurobiological substrates with antidepressants but act much faster, and by reducing residual symptoms, also minimise relapse. Written by four prominent clinical and research experts in psychiatry and circadian biology, the manual is designed to broaden the knowledge and practical application of chronotherapeutics. The step-by-step guide provides clear hands-on instructions supported by a solid body of clinical data. In addition, thirty independent contributors cover developing indications, explain the circadian timing system and sleep regulatory mechanisms that underlie these novel treatment strategies, and introduce the role of light in architecture for everyday health. The expanded third edition of Chronotherapeutics for Affective Disorders is essential reading for psychiatrists, psychologists and nurses, primary care physicians, and sleep medicine specialists. Further, it provides a unique source of information for inquisitive patients, their families, and the lay public.