Clear cell sarcoma of soft tissue (SCC) is one of the rarest and most difficult sarcomas to diagnose. It is often misdiagnosed as a malignant melanoma, which leads to inadequate therapeutic management, casting a shadow over the prognosis and evolution of patients.We started this project with the idea of cooperating with other professionals dedicated to the diagnosis and treatment of this type of sarcoma. This book provides help to those facing the battle against cancer, from general practitioners to specialised medical personnel. Its format has a logical and practical structure ranging from its concept and epidemiological behaviour to the future prospects of SCC. It is written in a simple and clear language that will enable the interested reader to understand the disease and work as a team to make decisions. We invite you to read it with the hope that it will serve as a useful, practical and safe tool at the end of your reading. It is not just about diagnosing and treating, it is about thinking, analysing and then making decisions, all for the benefit of our patients.